A highly enantioselective catalytic intramolecular Stetter reaction.
نویسندگان
چکیده
A family of chiral triazolium salts has been developed for inducing the asymmetric intramolecular Stetter reaction. The use of an aminoindanol-derived catalyst affords optimal results, with the product keto esters formed in 82-97% ee and very good chemical yield. Aromatic and aliphatic aldehydes are equally competent substrates for this reaction. The reaction conditions are reasonably mild and allow the isolation of the newly formed stereocenter without epimerization, although the presumed carbenic intermediates are strong bases.
منابع مشابه
A highly enantio- and diastereoselective catalytic intramolecular Stetter reaction.
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ورودعنوان ژورنال:
- Journal of the American Chemical Society
دوره 124 35 شماره
صفحات -
تاریخ انتشار 2002